"The Simpsons"`da, Homer Simpson, Abraham Simpson, Barney Gumble, Palyaço Krusty, Bahçıvan Willie, Belediye Başkanı Joe Quimby, Hans Moleman, Figuran Mel, The Itchy & Scratchy Show (Kıymık ve Tırmık) gibi birçok karakteri de seslendirmektedir.
1998`den önce, Castellaneta bölüm başına The Simpsons dizisinden 30 000 dolar almaktaydı. Castellaneta ve diğer 5 ana karakteri seslendirenler yapımcı şirket Fox`tan daha yüksek ücret talep ettiler.Şirketse onları yeni seslendirmeciler bulmakla biraz tehdit ettiyse de, 1998 ile 2004 arasında bölüm başına 125 000 dolara anlaştılar.Daha sonraki dönemde bölüm başına 360 000 dolar karşılığında seslendirmeye devam etmektedir.http://www.cbsnews.com/stories/2004/05/01/entertainment/main615066.shtml
Çalışmaları
Filmler
- ``The Beast with a Billion Backs`` (2008)
- ``The Simpsons Movie`` (2007)
- ``I Want Someone to Eat Cheese With`` (2007)
- ``The Pursuit of Happyness`` (2006)
- ``Casper`s Scare School`` (2006)
- ``I-See-You.Com`` (2006)
- ``The Jimmy Timmy Power Hour`` (2004)
- ``The Cat in the Hat`` (2003)
- ``The Secret Files`` (2003)
- ``Buttleman`` (2002)
- ``The Movie`` (2002)
- ``Return to Never Land`` (2002)
- ``Neil Simon`s Laughter On The 23rd Floor`` (2001)
- ``King of Dreams`` (2000)
- ``Space Jam`` (1996)
- ``Love Affair`` (1994)
- ``The Client`` (1994)
- ``The Return of Jafar`` (1994)
- ``Super Mario Bros.`` (1993)
- ``Don`t Tell Mom the Babysitter`s Dead`` (1991)
- ``The War of the Roses`` (1989)
- ``K-9`` (1989)
- ``The Thing that Ate Everybody`` (1989)
- ``Say Anything...`` (1989)
- ``Nothing in Common`` (1986)
Televizyon
- ``Monk`` (2008) - Pawnshop Owner in ``Mr. Monk Goes to the Bank``
- ``Greek`` (2007) - Dr. Milton Hastings
- ``Entourage`` (2007) - Andrew Preston
- ``That `70s Show`` (2006)
- ``Veronica Mars`` (2006)
- ``Legion of Super Heroes`` (2006) - Boris the Butler, Captain Howdy
- ``Complete Savages`` (2004-2005) (Episode - Free Lily) - Mr. Horner/Franklin the Frog
- ``Stargate SG-1`` (2004) Sci-fi series ("Stargate SG-1 - Citizen Joe")
- ``Arrested Development`` (2005) - Doctor Stein
- ``The Batman`` (2004) - Scarface
- ``The Unauthorized Story of Charlie`s Angels`` (2004)
- ``Frasier`` (Goodnight, Seattle) (2004) - Brad
- ``Everybody Loves Raymond`` (1998, 2003) - Coach Bryan
- ``Reba`` (2002 - 2003) - Eugene Fisher
- ``Yes, Dear`` (2001) - Walt
- ``Disney`s House of Mouse`` (2001)
- ``School`s Out`` (2001)
- ``Olive, the Other Reindeer`` (1999)
- ``Cow and Chicken`` (1997)
- ``Hey Arnold!`` (1996-2002) - Grandpa, The Jolly-Olly Man
- ``Friends`` (1996) - The Zoo Keeper in "The One After the Superbowl, Part One"
- ``Aladdin`` (1994-1996) - Genie
- ``Earthworm Jim`` (1994) - Jim
- ``Sonic the Hedgehog`` (1993) - Lazar the Wizard in ``Super Sonic``
- ``The Animated Series`` (1991-1993) - Doctor Emmett L. Brown
- ``Darkwing Duck`` (1991) - Megavolt
- ``Rugrats`` (1991 - 2003) - Johnathan
- ``Taz-Mania`` (1991)
- ``Fievel`s American Tails`` (1991) - Chula the Tarantula
- ``Dynamo Duck`` (199X) - Narrator
- ``Tale Spin`` (1990) TV Series
- ``Married...With Children`` (1990) - Pete
- ``The Simpsons`` (1989-present)
- ``The Tracey Ullman Show`` (1987-1990)
- ``Beyond the Magic Door`` (circa 1983) - Detective Farblonget
- ``Yes, Dear`` - Walt
- ``Futurama`` (various episodes between 1999 and 2003) Robot Devil (`Beelzebot`)
- ``The Tick`` - Plunger man, various characters
Başka
- ``The Simpsons Game`` (2007) (Video Oyunu) - Homer Simpson
- ``Kingdom Hearts II`` (2006) (Video Oyunu) - Genie
- ``Chain of Memories`` (2004) (Video Oyunu) - Genie
- ``I Am Not Homer`` (2003) (CD comedy)
- ``Kingdom Hearts`` (2002) (Video Oyunu) - Genie
- ``Two Lips`` (2000) (CD Beatles satire/homage)
- ``Torment`` (1999) (Video Oyunu) - Nordom
- ``Earthworm Jim 3D`` (1999) (Video Oyunu) - Earthworm Jim
- ``ClayFighter 63 1/3`` (1997) (Video Oyunu) - Earthworm Jim, Boogerman
- ``Toonstruck`` (1996) (Video Oyunu) - Flux Wildly
- ``American Splendor`` (Stage adaptation) - Harvey Pekar
